A research team from the University of Sydney and CMRI Westmead used 3D photolithographic printing to create functional human tissues that accurately mimic the architecture of organs.
Through bioengineering and cell culture skills, stem cells derived from blood and skin cells were guided to specialize and form structures resembling organs.
The developed method holds the potential to advance regenerative medicine and explore new treatments for various diseases by facilitating the development of tissues and organs in a lab setting.
Scientists Develop Method for 3D Printing Organ Structures Through Bioengineering.
Developed manual instruction for cells; Image: University of Sydney
A team of researchers from the University of Sydney and the Children's Medical Research Institute (CMRI) in Westmead has leveraged 3D photolithographic printing to fabricate functional human tissues that accurately mimic an organ’s architecture. The scientists used bioengineering and cell culture skills to instruct stem cells from blood cells and skin cells to specialize and form organ-like structures.
The project was led by Professor Hala Zreiqat and Dr. Peter Newman from the University of Sydney’s Biomedical Engineering department, along with Professor Patrick Tam who heads CMRI's Embryology Research Unit. The team's research paper titled "Programming of Multicellular Patterning with Mechano-Chemically Microstructured Cell Niches" has been published in "Advanced Science."
In the future, the research team will focus on advancing the field of regenerative medicine using their technique and exploring new treatments for various diseases.
"Our new method acts as a guide for cells, enabling them to create tissues that are better organized and more closely resemble their natural counterparts. This is an important step towards the possibility of 3D printing functional tissues and organs," commented Professor Hala Zreiqat.
